Since many diseasesare caused by the inappropriate expression of certain genes, the ability toselectively silence disease-associated genes represents a novel and powerfulmethod for treating disease. The primary challenge to achieving broadapplication of siRNA therapeutics is effective delivery of the molecules totarget tissues and cell types About Liquidia - Liquidia Technologies Inc. is a privately-held nanotechnologycompany that designs, develops, and manufactures precisely engineered particlesand films for a variety of life and materials science applications. Within lifesciences, Liquidia is focused on developing novel vaccines and Engineered DrugTherapies for nucleic acid delivery and inhaled therapeutics. The company wasfounded in 2004 on the discoveries of Professor Joseph DeSimone and colleaguesat the University of North Carolina, Chapel Hill and is located in ResearchTriangle Park, North Carolina. Liquidia TechnologiesElle Pishny, 919-328-4361; Copyright Business Wire 2009. My comments on Thanksgiving Day games can be found here: I WATCHEDNew Orleans Saints over New England Patriots, 38-17This was the marquee matchup of the weekend and it didn’t live up to its hype. 
The Saints spanked the Patriots like an unwanted step child.The shellacking the Patriots took at the hands of the Saints was a nasty reality check for New England Patriots fans. We must face the fact the Minnesota Vikings, New Orleans Saints, and even the Indianapolis Colts, are the elite teams in the league this year. We are a notch below, along with a handful of other teams, peeking our head over the windowsill wondering how we got left out the party.I’ll dispense with comments on the Saints in this game by simply saying they are a great team. Drew Brees is absolutely phenomenal and had an unbelievable performance. And defensive coordinator Greg Williams had a brilliant game plan and has really turned this defense around.

I’ve been utterly impressed with the Saints all year long and suffering through this game left me even more impressed. I expect to see a Saints versus Vikings matchup in the NFC Championship Game. They were able to get decent pressure on Brady, especially in the second half, with only a four man rush.This was partially because of injuries on our offensive line, which hopefully will get back in shape by seasons’ end. But the Patriots’ offense appears pretty easy to scheme against these days.We abandon the run way too soon and in the second half, like last week against the Jets, it was bombs away with nobody to throw the ball to.
They have been frequently out of place and burned all year by most teams we’ve faced.We have just gotten by with it, for the most part, because the offense has been putting up enough points to cover for them. The lousy play by the defensive backs was painfully evident on numerous blown coverages against the Saints. They should be embarrassed.I hope they are.Adding to our woes on defense we cannot get a pass rush or pressure the quarterback. Drew Brees had enough time in the pocket to eat a steak dinner and down a few drinks, much less throw the ball to his outstanding corps of receivers.